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Cheshkov, C; Guernane, R; Maire, A (Ed.)We present a Bayesian analysis, based on holography and constrained by lattice QCD simulations, which leads to a prediction for the existence and location of the QCD critical point. We employ two different parametrizations of the functions that characterize the breaking of conformal invariance and the baryonic charge in the Einstein-Maxwell-dilaton holographic model. They lead to predictions for the critical point that overlap at one sigma. While some samples of the prior distribution do not predict a critical point, or produce critical points that cover large regions of the phase diagram, all posterior samples present a critical point at chemical potentials µBc~550-630 MeV.more » « less
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Bellwied, R; Geurts, F; Rapp, R; Ratti, C; Timmins, A; Vitev, I (Ed.)We present results for a Bayesian analysis of the location of the QCD critical point constrained by first-principles lattice QCD results at zero baryon density. We employ a holographic Einstein-Maxwell-dilaton model of the QCD equation of state, capable of reproducing the latest lattice QCD results at zero and finite baryon chemical potential. Our analysis is carried out for two different parametrizations of this model, resulting in confidence intervals for the critical point location that overlap at one sigma. While samples of the prior distribution may not even predict a critical point, or produce critical points spread around a large region of the phase diagram, posterior samples nearly always present a critical point at chemical potentials of μBc∼ 550 − 630 MeV.more » « less
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Falsified antimalarial pharmaceuticals are a worldwide problem with negative public health implications. Here, we develop a surface-enhanced Raman scattering (SERS) protocol to recognize substandard and falsified antimalarial drugs present in commercially available tablets. After recording SERS spectra for pure chloroquine, primaquine, and doxycycline, SERS is used to measure these drugs formulated as active pharmaceutical ingredients (APIs) in the presence of common pharmaceutical caplet excipients. To demonstrate the viability of our approach, a red team study was also performed where low-quality and falsified formulations of all three drugs presented as unknowns were identified. These data in conjunction with promising results from a portable Raman spectrometer suggest that SERS is a viable technique for on-site analysis of drug quality.more » « less
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